Cyclospora infection is typically self-limited but may be prolonged and accompanied by progressive fatigue and weight loss. According to the CDC, the recommended treatment is a combination of two antibiotics: trimethoprim-sulfamethoxazole, also known as Bactrim, Septra, or Cotrim. It is advisable for people who have diarrhea to also rest and drink plenty of fluids. No equally effective treatments have been identified yet for people with Cyclospora infection who are unable to take sulfa drugs, such as those with allergies, pregnant or breastfeeding women, or pediatric patients. Some experimental studies, however, have suggested that ciprofloxacin or nitazoxanide may be effective, although to a lesser degree than trimethoprim-sulfamethoxazole.
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